Antihyperalgesic effect of [(±)-(2, 4, 6-cis)-4-chloro-6-(naphthalen-1-yl)-tetrahydro-2H-pyran-2-yl] methanol: participation of the NO/cGMP/KATP pathway and κ-opioid …

GM Gonçalves, SL Capim… - Behavioural …, 2016 - ingentaconnect.com
… and effect of (± )-cis-(6-ethyl-tetrahydropyran-2-yl) formic acid. … antinociceptive activity and
its pharmacological activity has … on the antinociceptive effects of morphine in mice. Methods …

[HTML][HTML] Antinociceptive effect and mechanism of action of isatin, N-methyl isatin and oxopropyl isatin in mice

TBS Giorno, BV da Silva, A da Cunha Pinto… - Life sciences, 2016 - Elsevier
… treatment mice were tolerant to the analgesic effect of … effect was observed only after 7 days
of consecutive treatment. Nevertheless, mice retained an effect and the antinociceptive effect

Synthesis and anticancer activities of novel guanylhydrazone and aminoguanidine tetrahydropyran derivatives

FPL Silva, BB Dantas, GV Faheina Martins… - Molecules, 2016 - mdpi.com
… That way, we performed in vitro evaluation for anticancer activity against cancer cell lines,
such as the … Other studies corroborate with our results, demonstrating increased activity of …

Synthesis of 16 New Hybrids from Tetrahydropyrans Derivatives and Morita-Baylis-Hillman Adducts: In Vitro Screening against Leishmania donovani

SC de Oliveira Sousa, J da Câmara Rocha… - Molecules, 2017 - mdpi.com
… )-cis,cis-6 [13,14] and recently the anti-hyperalgesic effect of is … (±)-cis-7 [16,17] presents
an analgesic effect in the same … from the acetic acid-induced abdominal writhes in mice to 6 = …

Avaliação farmacológica das atividades antinociceptiva e anti-inflamatória do composto (±)-4-cloro-6-(naftaleno-1-il)-tetrahidro-2h-pirano-2-il-metanol

GM Gonçalves - 2016 - tede.ufrrj.br
… The aim of this study was to evaluate the antinociceptive and … prototype acid, (±) - cis- (6-ethyltetrahydropyran-2-yl)
Formic. The … was able to induce antinociceptive activity in models of …